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According to Johns Hopkins Medicine, nicotine is used in both regular cigarettes and e-cigarettes

8-12 However, these studies were all limited in that they were either restricted to samples of males only 9,12 or failed to adjust for important smoke-related factors that could have confounded their findings, such as lifetime smoking (e.g., cigarette pack years or smoking duration), 10,11 current smoking status, 8,11 and smoking intensity