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Age, sex, race, and income were considered potential confounders in the relationship between smoking status and the occurrence of disorders based on a theoretical framework illustrated in the constructed Directed Acyclic Graph (DAG) (Supplementary file Figure 1)

At that time, the FDA stated it did not possess the ability to extend tobacco product regulations to these synthetic nicotine products

A better and more widespread understanding of what causes smoking-related diseases has helped pave the way for the development of potentially less harmful alternatives

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