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44 Bupropion is contraindicated in patients (1) with a seizure disorder, (2) with a history of anorexia or bulimia nervosa, (3) who are using another formulation of bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL), (4) who have used a monoamine oxidase inhibitor within the past 14 days, and (5) who are undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines)

It is also the stage when an individual may require substance abuse treatment, such as a dedicated detox program, to stop using substances