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The impact of antibiotics on immunotherapy efficacy has been suggested in other cancers but had not been specifically evaluated in cSCC, a population particularly vulnerable to antibiotic overuse due to frequent tumor ulceration and infection mimics, wrote Anne Pham-Ledard, MD, PhD, and colleagues

Our findings suggest that the altered EZH2/ H3K27me3/DAB2IP expression observed in COPD patients could be cause of an irregular proliferation in epithelial cells, present in the area of the metaplasia, known to be a pre-neoplastic change in response to toxic injury induced by cigarette smoke 5

Stage 1: Denial For many, the journey begins with denial