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Compared to smokers who reported no pain in the past 2 weeks, those with significant pain were 3 times more likely to use e-cigarettes and a greater number of nicotine products, and were approximately 4 times more likely to have tried e-cigarettes and 7 times more likely to have tried cigars [60]

Third, few studies have evaluated the association between smoking behaviors, including e-cigarette use, dual smoking, and SUA

PwCs Behind the Numbers 2025 pointed to three main drivers of rising costs: The increased uptake of expensive GLP-1 drugs like Ozempic and Wegovy, inflationary pressures and an increase in behavioral health services

In another study, female sex was similarly associated with a higher prevalence of functional digestive disorders 27