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The covariate selection algorithm flagged studies performed among populations that were not generalizable and those that used exposure definitions other than current SHS (for example, ever exposure to SHS) to be adjusted in our final model (Table 2)
Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function [see Use In Specific Populations ]
Even former pipe smokers retained elevated health risks compared to people who never used tobacco
One last consideration though is what the market is doing
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