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Key Facts About Starting Suboxone Key Facts People taking short-acting opioids (like heroin or Vicodin) typically wait 12 to 24 hours after the last dose.[1] People taking long-acting opioids (like morphine or OxyContin) typically wait 36 hours after the last dose.[1] You must show signs of withdrawal (like dilated pupils or goosebumps) before starting Suboxone

The key difference with smoke-free alternatives is that in general they do not require burning and thus, do not produce smoke