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The Food and Drug Administration (FDA) has authorized only 34 e-cigarette products under its Premarket Tobacco Application (PMTA) process as of late 2024, reflecting efforts to balance product safety with market access

Both PARPs and sirtuins have been recently involved in the maintenance of heterochromatin, a chromosomal domain associated with genome stability, as well as in transcriptional gene silencing, telomere integrity, and chromosome segregation during cell division (49, 50)

Informed consent was obtained from all patients for being included in the study