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In the setting of cigarette smoking, smokers are exposed to more than 7,000 components in its gaseous and particulate phases, including nicotine, direct carcinogens (such as acrolein, benzo-pyrenes, methylcholanthrene, and heavy metals), toxins (such as acetone, ammonia, carbon monoxide, and hydroquinone), oxidants (such as nitrogen oxides and superoxide), and reactive solids with chemically catalytic surfaces (Staempfli and Anderson, 2009