background information on tobacco History of Impacting African-American Communities Nicotine: The Good, The Bad

NF-B signaling pathways The transcription factor nuclear factor-kappa B (NF-kB) is an essential stressor in the cellular environment and regulates a series of genes involved in survival, oxidative stress, inflammation, and immunity [127]

During this process, the moisture content of fresh tobacco leaves drops from over 80% to below 20%, the color changes from green to yellow, and macromolecular substances (such as cellulose, pectin, and starch) degrade rapidly (Xing et al., 2025b)

10.1016/j.neuropharm.2020.108063 4

Brands are increasingly capitalizing on this trend by introducing products that cater to the Japanese markets preference for innovation and sustainability