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the included genetic variants, the genetic instrument, should (1) be robustly associated with the exposure variable, (2) not be associated with confounders of the relationship between exposure and outcome, and (3) not be associated with the outcome through any other path than the exposure [83]

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COVID-19 infection is currently the most prominent health challenge, and health decision-makers are looking for indicators to reduce the mortality and morbidity of the infection

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