In addition, existing evidence suggests no significant differences in serious adverse events, sleep disturbances, depression, or cardiovascular issues between combination NRT and NRT monotherapy
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But the company admitted it saw a disappointing performance in the US for cigarette brands like Camel, and an underwhelming start to the year for its Glo e-cigarette brand
113 Given potential monetary and feasibility challenges that were associated with reporting all 93 HPHCs on FDA's list, FDA released an accompanying 2012 draft guidance that provided an abbreviated list of HPHCs that manufacturers of cigarettes, smokeless tobacco, and roll-your-own tobacco would be required to report to FDA