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Reynolds Tobacco Company was the first company to produce chewing tobacco Works in the brain Chewing tobacco works in the brain by stimulating and releasing neurotransmitters, being dopamine, to produce that pleasurable and motivating It takes longer to reach the brain than smoking, do to it needs to travel into the blood stream until it hits the brain to function + = Symptoms and Withdrawals Symptoms that can occur from the use chewing tobacco are: Decrease of appetite Boosting of mood and even relieves minor depression Raise of blood sugar or increase of insulin production Increase bowel activity Saliva and phlegm Increase heart rate Blood pressure Sweating Nausea andDiarrhea Stimulation of memory and alertness

These results were run through CADIMA for removal of the duplicate studies, which gave a final of 3808 results (205 from pubmed

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