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in an artery supplying the brain it causes a stroke, and to learn the warning signs, see our guide to stroke

For example, a study on macrophage FAS found that IL-4 can activate sterol regulatory element-binding protein 1 (SREBP1), triggering the de novo lipogenesis (DNL) program, separating it from the cells antioxidant defense by depleting NADPH, thus increasing ROS levels