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When we performed two sample MR using a SmkInit IV from data that excluded UKBB participants (n = 50 SNPs), we identified negative effects on hemoglobin (Effect = -0.10 [-0.20 - -0.0004] SD units, P = 4.9x10 -2 ) and red blood cell count (Effect = -0.13 [-0.25 - -0.01] SD units, P = 4x10 -2 ) ( S4 Fig )

For an all-encompassing appraisal of SUD, it involves reviewing medical history, conducting psychological evaluations, and possibly performing substance testing

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