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Medications for COPD include long-acting muscarinic antagonists (LAMAs), long-acting beta-2 agonists (LABAs), inhaled corticosteroids (ICSs) plus LABAs, short-acting muscarinic antagonists (SAMAs), short-acting beta-2 agonists (SABAs), methylxanthines, systemic beta agonists, and phosphodiesterase-4 (PDE-4) inhibitor [4, 21, 22]