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Although useful for elucidating potential structural alterations among smokers, measures of gray matter are limited in their ability to inform interpretation of functional relations or behavioral implications

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In vivo and in vitro , M2-directed polarization related to the TGF-/Smad pathway in COPD was observed (29, 44), with the M2/M1 proportions generally negatively correlated with the lung function of mice (29), demonstrating the potential significance of the polarization state biased towards M2 macrophages in COPD

Hannah Cowan, MPH 1