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Secondary outcomes There was no clear evidence of a difference in post-intervention scores of heaviness of smoking (mean difference = 0.30, F (1,72) = 1.263, p = 0.27, motivation to stop smoking (mean difference = 0.46, F (1,72) = 2.012, p = 0.16) or autonomy over smoking (mean difference = 0.25, F (1,72) = 0.042, p = 0.84) between study arms with adjustment for the same measures taken at baseline (Table 2)

Discussion Our study and others provide evidence of impaired cardiac compensation in animal models of nicotine exposure

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The cause of costochondritis is usually unknown