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Health Effects of Cigarette Smoking Smoking and Death Smoking & Tobacco Use Cigarette smoking harms nearly every organ of the body, causes many diseases, and reduces the health of smokers in general.1,2 Quitting smoking lowers your risk for smoking-related diseases and can add years to your life.1,2 Smoking and Death Cigarette smoking is the leading cause of preventable death in the United States.1 Cigarette smoking causes more than 480,000 deaths each year in the United States