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Moreover, these exosomes were enriched in tissue factor (TF) and exerted a TF-dependent procoagulant activity compared with exosomes by unexposed cells [49], suggesting that TF + exosomes might contribute to the elevated cardiovascular risk in smokers and consider as biomarkers of exposure to CSE

Smoking has also been associated with an increased risk of developing certain gynecological conditions, such as endometriosis and early onset of menopause

Each cigarette contains 3 mg of tar and 0.2 mg of nicotine

[136] Tobacco-specific nitrosamines (TSNAs) such as nicotine-derived nitrosamine ketone (NNK) and N -Nitrosonornicotine (NNN) and tobacco-specific impurities have been found in the e-cigarette vapor at very low levels, [114] comparable to amounts found in nicotine replacement products