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Smoking decreases functional diversity of the epithelium To understand the effect of smoking habit, we first examined whether genes previously reported to be differentially expressed between current and never-smokers, based on bulk RNA-seq from bronchial airway epithelial brushings 9 , were similarly affected in each cell type independently

This gradual delivery helps manage withdrawal symptoms by maintaining a steady state of nicotine

I think this is also a cultural and attitude issue that we will not overcome