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As none of these thresholds (neither human data nor animal data) was available for the illicit drugs, LD50 values from animal experiments were selected instead and extrapolated to BMDL

However, roflumilast, a phosphodiesterase-4 inhibitor, appears to be more effective in patients with a neutrophilic phenotype, which may become a therapeutic agent for the neutrophil-mediated inflammatory response ( Therefore, there is a greater need to use specific biomarkers to predict the effect of treatment, such as specific proteins like serine proteases

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