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We have made some additional small edits to wording and phrasing in the introduction to clarify the aims of our study

For both studies, ethics approval was obtained from the University of South Carolina Institutional Review Board

On the sly I gathered a few of them, bathed them good in water, dried them and tied them and found them superior to fresh cut leaf tobacco. Otto even had the gall to call his product Excelsior, and explained that the bitter, oily nicotine having been squeezed out of it, it had a far sweeter flavor and taste. Otto kept his methods secret, but word inevitably got out, and soon every smoker would enter into a sort of contract with a chewer or two who would bind themselves to save the finished quid for him. Otto anticipated his readers disgust: Now I suspect good many will sniff their noses and call this a vile, nasty and vulgar proceeding, but to all such I humbly suggest to consider that it was not a whit more vulgar then eating of rotten stinky meat and sowbelly, the chewing of hardtack alive with fat, blockheaded maggots

"Oral lactase for infantile colic: a randomized double-blind placebo-controlled trial"