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Higher Incidence of Urinary Tract Infections (UTIs) Smoking weakens the immune system and damages the urinary tract, making smokers more prone to recurrent urinary tract infections (UTIs)

Stuart King James I wrote a famous polemic titled A Counterblaste to Tobacco in 1604, in which the king denounced tobacco use as "[a] custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse ." [13] That year, an English statute was enacted that placed a heavy protective tariff on tobacco imports

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198 Varenicline increased the likelihood of quitting compared with placebo, and some studies find that it is more effective than single forms of NRT 200,201 and bupropion