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It is a well-recognized regulator of cellular immunity since it has the capacity to stimulate the expression of secondary pro-inflammatory chemokines and growth factors in epithelial and mesenchymal cells and, thus, to mediate neutrophil recruitment and activation as well as neutrophil and macrophage accumulation in the lung tissue [282]

According to the company itself, iQOS cigarettes, while not burning, release vapors that contain toxic chemicals. Thus the same limitations that are on conventional cigarettes and on e-cigarettes must be applied to iQOS as well, they said