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Botulinum toxin type A (BTX-A) blocks the release of the neurotransmitter acetylcholine at the motor end plate terminals, thereby inhibiting the smooth muscle vasoconstriction [79]

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This has been borne out by the introduction of standard packs in Australia, which was associated with a 78% increase in calls to the smoking cessation Quitline in New South Wales, according to Association between tobacco plain packaging and Quitline calls: a population-based, interrupted time-series analysis

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