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"...[T]hrough the FDA's scientific evaluation of the company's applications, peer-reviewed published literature and other sources, the agency found that the aerosol produced by the IQOS Tobacco Heating System contains fewer toxic chemicals than cigarette smoke, and many of the toxins identified are present at lower levels than in cigarette smoke," the FDA said in a statement

Closed system products use pre-filled disposable cartridges or pods of vaping liquid which are not refillable

"This study shows a strong relationship between heavy smoking and chronic pain in women," Mannino said