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7 Side Effects of Nicotine Addiction Effects of Nicotine Addiction Adrenaline Overworks the Circulatory System Brain Chemistry Changes Blood Sugar Regulation Is Disrupted The Brain Reacts to Changes in Blood Flow and Hormones The Gastrointestinal System Is Disturbed Nicotine Addiction Develops Rapidly Physical Withdrawal Makes Quitting Difficult Nicotine is one of the most commonly used addictive substances in the United States