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Activation of nicotine-7nAChR signaling can trigger membrane depolarization, which activates voltage-gated calcium channels and subsequently activates the MAPK pathway, possibly increasing B-cell lymphoma-2 (Bcl-2) expression and apoptosis downregulation [111]
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"Cold sores are small ulcers, or blisters, on and around the lips that don't heal like other sores," Green says
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