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These can include: a weakened immune system because of illness or stress hormone changes, such as menstruation a vitamin deficiency, especially of folate and B12 intestinal issues, such as Crohns disease or ulcerative colitis, both types of inflammatory bowel syndrome (IBS) exposure to toxins in drinking water emotional or psychological stress smoking or a history of smoking Cold sores Cold sores look like fluid-filled blisters that appear near the mouth and lips

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