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Slowing momentum Duncan Cunningham, external affairs director at Philip Morris, says: In recent years, the decline of combustible cigarettes in the UK has been accompanied by significant areas of growth in smoking alternatives, such as vaping and heated tobacco

When heated, these compounds break down into formaldehyde , acetaldehyde , and acrolein toxic substances known to damage lung tissue and increase cancer risk

I had to fight very hard for the direction I believed in, he said

The following primary antibodies were used: anti-ATP7A (Santa Cruz Biotechnologies, Texas, USA, sc-376467), anti-CTR1 (abcam, Massachusetts, USA, #ab129067), anti-ABCG2 (Cell Signaling Technology, Massachusetts, USA, #42078), and -actin as a loading control (Cell Signaling Technology, Massachusetts, USA, #8457)