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Interaction of cadmium and zinc in biological samples of smokers and chewing tobacco female mouth cancer patients

From a harm reduction perspective, this may represent a public health gain

This addiction primarily stems from the presence of nicotine, a potent psychoactive substance found in tobacco, according to an article by the Center of Addiction and Mental Health titled Nicotine Dependence. The addictive nature of tobacco leads individuals to develop a tolerance, necessitating higher amounts to achieve the same effects, ultimately reinforcing the cycle of dependence

Other notable drugs inhaled via smoking include tetrahydrocannabinol (from cannabis), morphine (from opium), cocaine (from crack), and methamphetamine