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The involvement of oxidative stress mechanisms in DC activation and cytokine secretion includes a significant increase in protein oxidationmeasured by the formation of carbonyl radicalsand triggers p38 and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling, resulting in the upregulation of CD40

She writes the incident was both "harrowing and surreal" and calls the shooter, 20-year-old Thomas Matthew Crooks, a "monster" in a letter she later drafted on July, 14, 2024, written to the American people