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The brain adapts and gets used to the feeling, leading to more cravings for nicotine when not using tobacco, according to the study Biological basis of tobacco addiction: Implications for smoking-cessation treatment. Early Exposure to Nicotine: Individuals who start smoking or using tobacco at a young age are more likely to develop a stronger addiction

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Interventions for tobacco cessation in the dental setting Cochrane Database of Systematic Reviews

Simple and two way cross tabulations and multivariate logistic regression analysis were the main analytical methods