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The US which has the largest vape market in the world is nowhere near a nationwide ban, but there are signs of a shift among the states with five outlawing the sale of flavored e-cigarettes

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However, individuals with the altered form of ALDH2 who can tolerate the unpleasant effects of acetaldehyde and consume even moderate amounts of alcohol have a higher risk of alcohol-related esophageal and head and neck cancers than individuals with the normal enzyme who drink similar amounts of alcohol (31, 32)