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The audience, responding to the outburst, joined in with applause

1992 Ballot Petition In November 1992, a state ballot petition increased the cigarette tax 25 (from 21 to 51) and directed the state to spend some of the increased revenue on health education including an anti-smoking campaign

Smoking, primarily through the component nicotine, triggers an interaction with nicotinic acetylcholine receptors (nAChRs) on immune cells, particularly T cells and macrophages