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E-cigarettes are indeed harmful because they contain nicotine and other ingredients that can make people addicted, and long-term consumption is harmful to the human body

LaFaive, Todd Nesbit, and Ulrik Boesen, Analysis: Cigarette Smuggling Still a Problem, About to Get Much Worse, Mackinac Center for Public Policy, June 11, 2020, Michael D

In future studies, we will explore the use of Mendelian randomization to assess the causal relationship between tobacco exposure and constipation

Smokers often have social connections with other smokers, and quitting can lead to a sense of isolation or loss of social support, which can contribute to depressive symptoms