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NO is produced by the endothelial nitric oxide synthase (eNOS) and diffuses to the smooth muscle cells where it binds to the soluble guanylyl cyclase (sGC) that activates the cGMP-dependent protein kinase [63], leading to a reduction of intracellular calcium levels and thus to relaxation [53]

Seeping its way to the world on September 25, 2020, its title alludes to the phenomenon of aphantasia, or the inability for someone to create mental images of people, places, or objects

However, it is important to test whether people who only smoke cigarettes and do not vape would respond to messages about e-cigarettes as a reduced harm alternative to cigarettes in the same way as those who already both smoke and vape