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These claims are used to describe 1) that the product is made with nicotine created in a lab (i.e., tobacco-free nicotine, also known as synthetic nicotine or non-tobacco nicotine), or 2) that the product contains no tobacco leaf (i.e., tobacco-free or tobacco leaf-free)

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It is actually cultivated a little bit everywhere in the world (Mexico, United States of America, Africa...)

While I suggest in a comment at the PLoS ONE study site that we are seeing category crossover due to the studys dependency destroying definition of cold turkey ("gave up cigarettes all at once" instead of the actual definition, "abrupt complete cessation of the use of an addictive drug"), Table 7 footnotes indicate that there was also "missing data." Regardless, cold turkey crushed the competition