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Multiple single-cell studies, including global scRNA-seq analyses of COPD alveolar regions and airway terminals, have uncovered a complex network of ligandreceptor interactions among basal cells, resident fibroblasts, and immune cells

Activated Parkin can ubiquitinate the anion potential channel protein VDAC1 (voltage-dependent anion channel 1) in damaged mitochondria, which is recognized by the signal adapter protein P62/SQSTM1 (sequestosome 1) and then connects with Atg8 family homologous proteins (LC3, etc.) on the phagocytic membrane surface to initiate mitophagy [16]

This enhancement can lead to better absorption and excretion of bowel-cleansing agents and a better tolerance of the patients [85]

"In 2020 and 2021, the air quality was relatively better but it later returned to poor quality