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The rate of HNB tobacco users was relatively lower relative to other products, at 1.3% (95% CI: 1.3, 1.3)/0.9% (95% CI: 0.9, 0.9)/1.1% (95% CI: 1.0, 1.2) among junior high school students, and 2.9% (95% CI: 2.8, 3.0)/1.4% (95% CI: 1.4, 1.4)/2.2% (95% CI: 2.0, 2.4) among high school students

Recently, a sub-chronic whole-body exposure of e-liquid (2 h/day, 5 days/week, 30 days) containing PG alone or PG with nicotine (25 mg/mL) to wild type (WT) animals or knockout (KO) mice in 7 nicotinic acetylcholine receptor (nAChR7-KO) revealed a partly nAChR7-dependent lung inflammation [42]

This rule is for all drivers in England and Wales, even if you're 17 or just have a learner's permit