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However, more studies are needed in this region to better ascertain the prevalence of use and changes over time

This difference between BEAS-2B and 16HBE implies a cell line specific response to CSE exposure and may indicate that 16HBE cell line is less sensitive to cigarette smoke [49], which may be due to the more robust barrier function of 16HBE cells compared to BEAS-2B cells [46]

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They are especially popular for social occasions where guests may appreciate something a bit different