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"Treatment" of sad emotional states with nicotine over time may also impair innate restorative responses, just as treatment of chronic pain with opioids results in many patients experiencing hyperalgesia, a pathologically heightened response to painful stimuli
Terry, Chairman, World Conference on Smoking and Health, at the opening general session Monday morning, September 11, 1967 Identified in the Tobacco Industry Documents Library We have come to the end of one era in the smoking and health field
Furthermore, a synergistic effect between smoking and alcohol consumption on elevated ALT levels has been observed in HCV patients, indicating that the combined exposure significantly exacerbates liver injury [84]
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