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Strengths and limitations The strengths of this review include an a priori established study protocol with clear inclusion and exclusion criteria, development of search strategy by consultation with an information specialist, consideration of study design, specific/precise definition of e-cigarette use exposures (i.e., exclusive, daily, and occasional e-cigarette users) to further clarify the associations with various comparison groups (i.e., non-smokers, smokers, and dual users), and use of GRADE to assess the certainty of evidence associated with e-cigarette use

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