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The Tobacco 21 initiative has been successful in many states, counties and cities across the country, as seen in the map below with statewide age 21 restrictions highlighted in yellow, and varying age restrictions highlighted in green

One things for sure: The growing availability of varied ZYNs gives nicotine consumers over the age of 21 a greater range of choice than ever before

The main toxic ingredient in cigarettes and other tobacco products is nicotine

doi:10.1126/scitranslmed.3003062 pmid:22049069 Li X, Semenova S, D'Souza MS, Stoker AK, Markou A (2014) Involvement of glutamatergic and GABAergic systems in nicotine dependence: implications for novel pharmacotherapies for smoking cessation