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Description

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Being highly ionizing, with high linear energy transfer (LET) and a short range, they are recognized as the main contributors to lung tissue dose through the induction of complex DNA damage in the bronchial epithelium, including clustered lesions and double-strand breaks (DSBs) ( 3.3.1.1.3 Generation of reactive oxygen species Both tobacco smoke and radon contribute to the formation of reactive oxygen species (ROS), which play a central role in oxidative DNA damage and carcinogenesis

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