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In brown adipose tissue, a deficiency in thioredoxin-2, which scavenges mtROS, mitigates excessive ROS accumulation by inhibiting the Cyclic GMP-AMP Synthase (cGAS)/Stimulator of Interferon Genes (STING) and NOD-like Receptor Pyrin Domain Containing 3(NLRP3)inflammasome pathways, thereby protecting mitochondrial membrane integrity and reducing mtDNA oxidative damage and escape (Huang et al., 2022)
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