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18 : 12631271 Denissenko M, Pao A, Tang M-S, Pfeifer G

Newborns whose mothers smoked were at about a 50% to 70% greater risk for anomalies of the valve and vessels that carry blood to the lungs (pulmonary valve and pulmonary arteries) and about a 20% greater risk for holes in the wall separating the two collecting chambers of the heart (atrial septal defects)

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The cardiovascular system is affected early Nicotine and combustion products cause blood vessel spasms, raise blood pressure, and accelerate the formation of atherosclerotic plaques