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These symptoms may include irritability, anxiety, difficulty concentrating, increased appetite, and intense cravings for tobacco [2]

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Diffusion-limited, these channels allow adenosine to diffuse freely across the cellular membrane, following its concentration gradient ( Purinergic Signaling in Acute Pulmonary Inflammation Extracellular nucleotides and nucleosides (particularly ATP and adenosine) along with the ectonucleotidases CD73 and CD39 (responsible for the conversion of ATP to adenosine) and nucleoside transporters (ENTs) have been demonstrated to play essential roles in the pathogenesis of acute pulmonary inflammation (Figure 3)