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In a small single-center study, higher levels of total cf-DNA (measured by spectrophotometry) were detected in the plasma of patients with COPD exacerbations admitted to the hospital compared to COPD patients without exacerbations and healthy controls, and were associated with an increased risk of 5-year mortality (37)
Disseminated intravascular coagulation and platelet dysfunction, both of which are known to occur in acute CNS insults, can compromise the integrity of the pulmonary capillary endothelium, facilitating the leakage of protein-rich fluid into the alveolar spaces [18]
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